Swiss HIV Cohort Study

Raffenberg et al., Auswirkung des Aufschubs einer antiretroviralen Behandlung während einer ganz frischen HIV-Infektion auf die Telomerlänge

Auswirkung des Aufschubs einer antiretroviralen Behandlung während einer ganz frischen HIV-Infektion auf die Telomerlänge.   Journal of Infectious Diseases Menschen, die mit HIV leben, haben heutzutage ungefähr die gleiche Lebenserwartung wie die Personen ohne HIV. Dies ist vor allem dank der stetig weiterentwickelten HIV-Medikamente möglich, der sogenannten antiretroviralen Therapie (ART). Menschen mit HIV könnten heutzutage […]

Muller et al., Immunophenotypic characterization of TCR γδ T cells and MAIT cells in HIVpos developing HL

Immunophenotypic characterization of T-cell receptor γδ T cells and mucosal-associated invariant cells in HIV-infected individuals developing Hodgkin’s lymphoma.   Infectious Agents and Cancer T-cell receptor (TCR) γδ cells and/or mucosal-associated invariant T (MAIT) cells might be associated with the increased risk of non-AIDS defining cancers (NADCs) because both serve as a link between the adaptive […]

Boettiger et al., Cost-effectiveness of statins for primary prevention of atherosclerotic cardiovascular disease among people living with HIV

Cost-effectiveness of statins for primary prevention of atherosclerotic cardiovascular disease among people living with HIV in the United States.    Journal of the International AIDS Society Boettiger et al. aimed to evaluate the cost-effectiveness of pravastatin and pitavastatin for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) among people living with HIV (PLHIV) in the […]

Atkinson and Miro et al., No need for secondary PjP pneumonia prophylaxis in adult people living with HIV from Europe on ART with suppressed viraemia and a CD4 cell count >100 cells/µL

No need for secondary Pneumocystis jirovecii pneumonia prophylaxis in adult people living with HIV from Europe on ART with suppressed viraemia and a CD4 cell count greater than 100 cells/µL.   Journal of the International AIDS Society Atkinson and Miro et al. assessed the influence of CD4 cell count, HIV viral load and use of antimicrobial […]

Sculier at al., Efficacité et sécurité de l’association dolutegravir + emtricitabine pour le traitement de maintenance du VIH en comparaison des combinaisons antirétrovirales standards

Efficacité et sécurité de l’association dolutegravir + emtricitabine pour le traitement de maintenance du VIH en comparaison des combinaisons antirétrovirales standards: résultats de l’étude SIMPL’HIV, une étude factorielle, randomisée, de non-infériorité.   PLoS Medicine La simplification de traitement chez les personnes vivant avec le VIH est un sujet d’études depuis plusieurs années déjà. La simplification […]

Sculier et al., Efficacia e sicurezza della combinazione dolutegravir + emtricitabina per il trattamento di mantenimento dell’HIV comparata con le combinazioni antiretrovirali standard

Efficacia e sicurezza della combinazione dolutegravir + emtricitabina per il trattamento di mantenimento dell’HIV comparata con le combinazioni antiretrovirali standard: risultati dello Studio SIMPL’HIV, uno studio fattoriale, randomizzato di non inferiorità. PLoS Medicine La semplificazione del trattamento nelle persone che vivono con HIV è oggetto di studio da molti anni. La semplificazione comprende la diminuzione […]

Sculier et al., Wirksamkeit und Sicherheit von Dolutegravir + Emtricitabin zur HIV-Erhaltungstherapie im Vergleich zu antiretroviralen Standardkombinationen

Wirksamkeit und Sicherheit von Dolutegravir + Emtricitabin zur HIV-Erhaltungstherapie im Vergleich zu antiretroviralen Standardkombinationen: Ergebnisse der SIMPL’HIV-Studie, einer faktoriellen, randomisierten, Nicht-Unterlegenheit Studie.    PLoS Medicine Die Vereinfachung der Behandlung von Menschen, die mit HIV leben, ist schon seit einigen Jahren das Thema diverser Studien. Die Vereinfachung umfasst die Verkleinerung der Anzahl und/oder der Dosis der […]

Raffenberg et al., Primary HIV infection ART delay on telomere length

Impact of delaying antiretroviral treatment during primary HIV infection on telomere length.   Journal of Infectious Diseases Telomere length (TL) shortens during aging, HIV seroconversion, and untreated chronic HIV infection. In this work, Raffenberg et al. aimed to evaluate any independent association of the time of antiretroviral therapy (ART) start with TL in participants with […]

Tarr et al., Longitudinal CAC/CCTA HIV-pos vs HIV-neg

Longitudinal progression of subclinical coronary atherosclerosis in Swiss HIV-positive compared with HIV-negative persons undergoing coronary calcium score scan and CT angiography.   Open Forum Infectious Diseases Tarr et al. investigated whether HIV infection accelerates the progression of atherosclerosis over time comparing coronary computed tomography angiography (CCTA) of people with and without HIV infection. Changes in […]

Nguyen et al., Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link.   eLive Nguyen et al. assessed whether certain human leukocyte antigen (HLA) class I alleles play a role in the development of HIV drug resistance mutations among untreated people with HIV. SHCS participants with available HIV drug resistance testing and […]