Kraef et al., Incident TB in PWH across Europe from 2012 to 2022
Incident tuberculosis in people with HIV across Europe from 2012 to 2022: incidence rates, risk factors and regional differences in a multicentre cohort study The aim of this study is to describe the incidence of TB, evaluate the impact of modifiable risk factors, in particular being off antiretroviral therapy and smoking and to calculate their […]
Labarile et al., Untarget metabolite profile associations with BMI, waist-hip ratio and ART in PWH
Untargeted Metabolite profile associations with Body Mass Index, waist-hip ratio, and antiretroviral therapy in >1300 people with HIV: the Swiss HIV Cohort Study Labarile et al. analyzed the metabolic profiles of 1’302 people with HIV (PWH) in Switzerland to understand how obesity and different antiretroviral therapies (ART) are linked to changes in blood metabolites. The […]
Abela et al., Differenze di genere nella prescrizione di statine a persone affette da HIV e con rischio basso/medio-alto di malattie cardiovascolari
Differenze di genere nella prescrizione di statine a persone affette da HIV e con rischio basso/medio-alto di malattie cardiovascolari. Grazie ai farmaci moderni, oggi le persone affette da HIV hanno un’aspettativa di vita simile a quella delle persone sieronegative. Tuttavia, permane un rischio più elevato di malattie cardiovascolari, come infarto o ictus. I farmaci, come […]
Abela et al., Différences de genre dans la prescription de statines chez les personnes vivant avec le VIH présentant un risque faible/moyen à élevé de maladies cardiovasculaires
Différences de genre dans la prescription de statines chez les personnes vivant avec le VIH présentant un risque faible/moyen à élevé de maladies cardiovasculaires. Grâce aux médicaments modernes, les personnes vivant avec le VIH ont aujourd’hui une espérance de vie similaire à celle des personnes ne vivant pas avec le VIH. Elles présentent néanmoins un […]
Abela et al., Geschlechtsspezifische Unterschiede bei der Verschreibung von Statinen bei Menschen mit HIV und niedrigem/mittlerem bis hohem Risiko für Herzkreislauferkrankungen
Geschlechtsspezifische Unterschiede bei der Verschreibung von Statinen bei Menschen mit HIV und niedrigem/mittlerem bis hohem Risiko für Herzkreislauferkrankungen. Menschen mit HIV haben heute dank moderner Medikamente eine ähnliche Lebenserwartung wie Menschen ohne HIV. Trotzdem haben sie ein höheres Risiko für Herz-Kreislauf-Erkrankungen, wie Herzinfarkte oder Schlaganfälle. Medikamente wie Statine, welche zur Cholesterinsenkung eingesetzt werden, können dieses […]
Audige et al., SARS-CoV-2 T-cell assay agreement
Low agreement between SARS-CoV-2 T-cell assays in immunocompromised individuals T-cell responses are an important component of immunity against SARS-CoV-2, especially in people with compromised immune systems where antibody responses may be suboptimal. Commercial interferon-γ release assays (IGRAs) have become available to measure SARS-CoV-2–specific T-cell responses, but their reliability in such populations remains uncertain. Audigé and […]
Harney et al., Unsuccessful DAA HC treatment among PWH
Unsuccessful direct-acting antiviral Hepatitis C treatment among people with HIV: Findings from an international cohort Successful treatment of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) is now expected in almost all people with HIV (PWH). However, a small proportion still do not achieve cure, and understanding the reasons for unsuccessful treatment remains important […]
Schoepf et al., Longitudinal time trends of LTFs in PWH
In the present study, Schoepf et al investigated time trends of low trauma fractures in people with HIV. The authors benefited from the standardized data collection on fractures in the SHCS, which is implemented since 2008. They estimated low trauma fractures incidence rates per calendar year from 2009 to 2022 and adjusted for clinical and […]
Zeeb et al., Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1
Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1 This week we highlight the study by Zeeb et al., published in PLOS Pathogens, which offers new insights into how latent tuberculosis (TB) infection shapes the immune response to HIV. This work builds on the long-standing contributions of the Swiss HIV Cohort Study (SHCS), which […]
Hesselmann et al., Rare twin cysteine residues in HIV-1 Env and neutralization breadth
Rare twin cysteine residues in HIV-1 Env and neutralization breadth This week we highlight the study by Hesselman et al., published in Cell Host & Microbe and awarded the SSI Award in Basic Research, titled “Rare twin cysteine residues in HIV-1 Env and neutralization breadth.” Broadly neutralizing antibodies (bnAbs) against HIV-1 typically target the viral […]