Santos et al., Depressive symptoms and NCI in people with well-treated HIV in CH
Association between depressive symptoms and neurocognitive impairment in people with well-treated HIV in Switzerland.   International Journal of STD & AIDS Santos et al. aimed to analyse the association between depressive symptoms and neurocognitive impairment (NCI) in a population of well-treated, ageing people with HIV (PWH). PWH aged ≥45 years underwent neurocognitive assessment and grading […]
Wan et al., Héritabilité de la taille du réservoir du VIH-1 et modification sous traitement suppressif à long terme
Héritabilité de la taille du réservoir du VIH-1 et modification sous traitement suppressif à long terme.   Nature Communications La thérapie antirétrovirale peut réduire considérablement la mortalité et la morbidité causées par le VIH, mais elle doit être prise à vie pour y parvenir. La raison en est que si cette thérapie peut efficacement stopper […]
Wan et al., Ereditabilità della dimensione del serbatoio HIV-1 e modifica sotto terapia soppressiva a lungo termine
Ereditabilità della dimensione del serbatoio HIV-1 e modifica sotto terapia soppressiva a lungo termine.   Nature Communications La terapia antiretrovirale riduce in modo sostanziale la mortalità e la morbilità causate dall’HIV, ma per ottenere questo risultato dev’essere assunta a vita. In effetti tale terapia, pur inibendo efficacemente la replicazione dell’HIV, non conduce a un’eliminazione del […]
Wan et al., Vererbbarkeit der HIV-1 Reservoir-Grösse und Veränderung unter langzeitunterdrückender ART
Vererbbarkeit der HIV-1 Reservoir-Grösse und Veränderung unter langzeitunterdrückender ART.   Nature Communications Die antiretrovirale Therapie kann die durch HIV verursachte Mortalität und Morbidität stark reduzieren, muss hierzu aber lebenslang eingenommen werden. Der Grund hierfür ist, dass diese Therapie zwar die Vermehrung von HIV effizient stoppen kann, aber nicht zu einer vollständigen Elimination des Virus führt. […]
Meier et al., Immune response against Mtb in HIV
HIV-infected patients developing tuberculosis disease show early changes in the immune response to novel Mycobacterium tuberculosis antigens. frontiers in Immunology Meier et al. performed a case-control study to evaluate the utility of novel M. tuberculosis antigens for early diagnosis of tuberculosis (TB) in people with HIV. Authors included patients in the Swiss HIV Cohort Study […]
Courlet et al., Pharmacokinetic parameters and weight change in HIV patients newly switched to dolutegravir-based regimes
Pharmacokinetic parameters and weight change in HIV patients newly switched to dolutegravir-based regimens in SIMPL’HIV clinical trial. Â Â British Journal of Clinical Pharmacology Courlet et al. aimed to evaluate the association between dolutegravir (DTG) pharmacokinetic parameters and weight changes in treatment-experienced people with HIV (PWHIV) from the Simpl’HIV study newly switched to a dual DTG-based […]
Kovari et al., ALT changes after switching from TDF to TAF in HIV-monoinfected people
Changes in alanine aminotransferase levels after switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) in HIV-positive people without viral hepatitis in the Swiss HIV Cohort Study.  HIV Medicine Kovari et al. assessed the impact of switching from TDF to TAF on alanine aminotransferase (ALT) in people with HIV. Authors included all patients without […]
Castillo-Mancilla et al., Incomplete ART adherence and cardiovascular events and mortality
Association of incomplete adherence to antiretroviral therapy with cardiovascular events and mortality in virologically suppressed persons with HIV: The Swiss HIV Cohort Study. Â Â Open Forum Infectious Diseases Castillo-Mancilla et al. aimed to assess the clinical implications of incomplete antiretroviral therapy (ART) adherence on the occurrence of cardiovascular events (CVD) and non-CVD-related death. Persons with […]
Surial et al., Impact of binge drinking on mortality and liver disease
The impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. Â Â Journal of Clinical Medicine Surial et al. assessed whether binge drinking contributes to all-cause and liver-related mortality and to the occurrence of liver-related events among people living with HIV. Previous reports from the general population showed that individuals […]
Hovaguimian et al., Long-term risk of HIV infection in individuals seeking post-exposure prophylaxis
Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis. Â Nature Communications Hovaguimian et al. aimed to estimate the long-term risk of HIV infection in post-exposure prophylaxis (PEP-) seekers in a tertiary referral center. As previous evidence suggests that sexual risk taking occurs in phases lasting 12 to 24 […]