Swiss HIV Cohort Study

Kusejko et al., Déficits neurocognitifs chez les patient·e·s de la SHCS

Déficits neurocognitifs chez les patient·e·s de la SHCS Les déficits neurocognitifs (troubles de la mémoire, déficit d’attention, problème de prise de décision) sont fréquents chez les personnes infectées par le VIH. A l’aide de tests neuropsychologiques, des études antérieures ont montré qu’environ la moitié des séropositifs souffraient de déficits neurocognitifs. Cette étude a analysé combien […]

Olearo et al., M184V/I impact in ART-experienced patients

Impact of the M184V/I mutation on the efficacy of abacavir / lamivudine / dolutegravir therapy in human immunodeficiency virus treatment-experienced patients.    Open Forum Infectious Diseases Olearo et al. aimed to conduct a prospective study using data from 5 large HIV cohorts in four European countries (France, Italy, the Netherlands and Switzerland) to assess the […]

Courlet et al., Escitalopram population pharmacokinetics in PLWH and in the psychiatric population

Escitalopram population pharmacokinetics in people living with human immunodeficiency virus and in the psychiatric population: Drug-drug interactions and probability of target attainment.    British Journal of Clinical Pharmacology Courlet et al. aimed to develop (i) a population pharmacokinetics model for escitalopram in people living with human immunodeficiency virus (PLWH) and uninfected psychiatric individuals; (ii) to […]

Bachmann et al., Serbatoi dell’HIV: nuove scoperte sugli ostacoli tenaci nel percorso verso la guarigione

Serbatoi dell’HIV: nuove scoperte sugli ostacoli tenaci nel percorso verso la guarigione.   Nature Communications I serbatoi di cellule infettate in modo latente dall’HIV rappresentano un ostacolo maggiore alla guarigione. Sono composti principalmente da cellule memoria T-CD4+ infette, ma in stato di riposo. Questi serbatoi si formano rapidamente dopo il contagio da HIV e sopravvivono […]

Bachmann et al., HIV-Reservoirs: Neue Erkenntnisse über die zähen Gegner auf dem Weg zur Heilung

HIV-Reservoirs: Neue Erkenntnisse über die zähen Gegner auf dem Weg zur Heilung.    Nature Communications Eine der grössten Hürden für die Heilung von HIV stellt das Reservoir von latent HIV-infizierten Zellen dar. Diese bestehen vor allem aus infizierten, jedoch ruhenden CD4+ T-Gedächtniszellen. Diese Reservoirs bilden sich rasch nach der HIV-Infektion und überdauern auch eine jahrzehntelange […]

Bachmann et al., Réservoirs VIH: nouvelles découvertes sur des obstacles majeurs à la guérison

Réservoirs VIH: nouvelles découvertes sur des obstacles majeurs à la guérison.   Nature Communications Les réservoirs de cellules infectées par le VIH de manière latente représentent un obstacle majeur à la guérison. Ces réservoirs sont composés avant tout de cellules mémoires CD4+ T infectées mais au repos. Ces réservoirs se forment rapidement après la contamination […]

Tate et al., Improved risk index for people with HIV infection

Albumin, white blood cell count, and body mass index improve discrimination of mortality in HIV-positive individuals.    AIDS The Veterans Aging Cohort Study (VACS) Index incorporates clinical biomarkers of general health with age, CD4+ cell count, and HIV-1 RNA to discriminate mortality risk in a variety of HIV-positive populations. In the current study, the author […]

Chan et al., Predictors of viral suppression in infants with perinatal HIV

Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand.    AIDS Chan et al. on behalf of the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) aimed to investigate predictors of faster virological suppression, focusing on infants with perinatal HIV initiating standard combination antiretroviral therapy (cART) living in […]

Künzler-Heule et al., Screening HIV-positive MSM for HCV-infection risk using a single question on condom-use

Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis.   BMC Infectious Diseases Künzler-Heule et al. aimed to (1) describe sexual and drug-using behaviours participants reported during Swiss HCVree study baseline assessment and to compare those behaviours in men who have […]

Euler et al., Neutralizing antibody responses in HIV-1 infected injecting drug users

Lower broadly neutralizing antibody responses in female versus male HIV-1 infected injecting drug users.   Viruses Euler et al. studied the prevalence of broadly neutralizing antibody (bNAb) responses in HIV-1 infected individuals in the Amsterdam Cohort, including 50 male and 35 female participants who reported injecting drug use as the only risk factor. The study revealed […]