Surial et al., Switching from TDF to TAF in the SHCS
Rates and predictors of switching to tenofovir alafenamide-containing ART in a nationwide cohort.   BMC Infectious Diseases Surial et al. aimed to determine the proportion of patients with and without risk factors for tenofovir disoproxil fumarate (TDF-) related toxicity who had been switched from TDF to tenofovir alafenamide fumarate (TAF) and explored individual predictors for being […]
Olearo et al., Influsso della mutazione M184V/I sull’efficacia della terapia combinata Triumeq® nei pazienti pretrattati per l’HIV
Influsso della mutazione M184V/I sull’efficacia della terapia combinata Triumeq® nei pazienti pretrattati per l’HIV.  Open Forum Infectious Diseases Nei pazienti che hanno un fallimento virologico a causa di una scarsa aderenza terapeutica o come conseguenza di una terapia efficace solo in parte, possono apparire nel genoma dell’HIV dei segmenti con mutazioni. Queste mutazioni possono […]
Olearo et al., Einfluss der M184V/I Mutation auf die Wirksamkeit der Kombinationstablette Triumeq® bei behandlungserfahrenen Patienten
Einfluss der M184V/I Mutation auf die Wirksamkeit der Kombinationstablette Triumeq® bei behandlungserfahrenen Patienten.   Open Forum Infectious Diseases. Bei Patienten, welche aufgrund einer schlechten Therapietreue oder einer nicht voll wirksamen HIV-Therapie ein virologisches Versagen machen, können Mutationen in bestimmten HIV-Genabschnitten auftreten, welche zu einer Resistenz auf gängige HIV-Medikamente führen. Die häufigste Resistenzmutation in der Schweizerischen […]
Olearo et al., Influence de la mutation M184V/I sur l’efficacité du comprimé associé Triumeq® chez les patients prétraités
Influence de la mutation M184V/I sur l’efficacité du comprimé associé Triumeq® chez les patients prétraités.  Open Forum Infectious Diseases Des mutations peuvent apparaître dans certains segments du gène VIH chez des patients qui sont en échec virologique à cause d’une mauvaise observance thérapeutique ou d’une thérapie partiellement efficace. Ces mutations peuvent être la cause […]
Young et al., NRTI-sparing dual regimens
The comparative effectiveness of NRTI-sparing dual regimens in emulated trials using observational data from the Swiss HIV Cohort Study. Â Antiviral Therapy Young et al. used data from the Swiss HIV Cohort Study to estimate the effectiveness of dolutegravir dual regimens relative to alternative NRTI-sparing dual regimens. For that, they emulated two trials by propensity […]
Mocroft et al., Clinical outcomes in persons coinfected with HIV and HCV
Clinical outcomes in persons coinfected with human immunodeficiency virus and hepatitis C virus: impact of hepatitis C virus treatment.  Clinical Infectious Diseases Mocroft et al. on behalf of the EuroSIDA Study aimed to investigate clinical outcomes in a large, European, multi-cohort study, according to hepatitis C (HCV) status in HIV-coinfected persons from across Europe, […]
Lodi et al., Effectiveness of transmitted drug resistance testing
Effectiveness of transmitted drug resistance testing before initiation of antiretroviral therapy in HIV-positive individuals.  JAIDS Lodi et al. on behalf of the HIV-CAUSAL Collaboration aimed to estimate the effectiveness of transmitted drug resistance (TDR) testing, when used according to current guidelines, on virological and clinical outcomes up to 5 years after HIV diagnosis among individuals […]
Hatleberg et al., Predictors of ischemic and hemorrhagic strokes among people living with HIV
Predictors of ischemic and hemorrhagic strokes among people living with HIV: The D:A:D International Prospective Multicohort Study.  EClinical Medicine Hatleberg et al. for the Data Collection on Adverse events of anti-HIV Drugs (D:A:D) Study Group aimed to investigate systematically whether hypertension, other common cardiovascular disease (CVD) risk factors and HIV-related factors were differently associated with […]
Kusejko et al., Disturbi neurocognitivi nei pazienti della SHCS
Disturbi neurocognitivi nei pazienti della SHCS I disturbi neurocognitivi (disturbi della memoria, deficit dell’attenzione, difficoltà nel prendere decisioni) sono frequenti nelle persone con infezione da HIV. Con l’aiuto di test neuropsicologici, studi precedenti hanno mostrato che circa la metà delle persone sieropositive soffrono di disturbi neurocognitivi. L’attuale studio ha verificato quanti pazienti dello Studio svizzero […]
Kusejko et al., Neurokognitive Einschränkungen bei Patienten*innen aus der SHCS
Neurokognitive Einschränkungen bei Patienten*innen aus der SHCS Neurokognitive Einschränkungen (Gedächtnisstörungen, Aufmerksamkeitsdefizite, Probleme bei Entscheidungsfindungen) sind bei HIV-infizierten Personen häufig. Frühere Studien kamen zum Schluss, dass bei Untersuchungen mittels neuropsychologischer Tests bis die Hälfte aller HIV-infizierter Personen eine solche neurokognitive Einschränkung aufwiesen. Die vorliegende Studie hat nun untersucht, wie oft eine neurokognitive Einschränkung bei den Patienten*innen […]