Vannappagari et al., Taux de malformations chez les nouveau-nés lors de traitement avec dolutegravir pendant la grossesse
Taux de malformations chez les nouveau-nés lors de traitement avec dolutegravir pendant la grossesse.   Pregnancy and neonatal outcomes following prenatal exposure to dolutegravir. Dolutegravir fait partie des substances anti-VIH les plus fréquemment prescrites à l’échelle mondiale. Une étude antérieure faite au Botswana/Afrique a laissé supposer que les femmes qui étaient sous traitement avec dolutegravir […]
Neesgaard et al., Uptake and effectiveness of 2DR versus 3DR
Uptake and effectiveness of two-drug compared with three-drug antiretroviral regimens among HIV-positive individuals in Europe. Â Â AIDS Neesgaard et al. on behalf of the EuroSIDA study analysed the uptake of two-drug antiretroviral regimens (2DRs), factors associated with starting or switching to a 2DR in the European-based EuroSIDA cohort, and virologic and immunologic outcomes of using […]
Metral et al., Screening questions for neurocognitive impairment
How helpful are the European AIDS Clinical Society cognitive screening questions in predicting cognitive impairment in an aging, well-treated HIV-positive population?   HIV Medicine Metral et al. for the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study group from the Swiss HIV Cohort Study aimed to determine the positive and negative predictive values (PPVs […]
Borges et al., SMART and START combined analysis
The effect of interrupted/deferred antiretroviral therapy on disease risk: A SMART and START combined analysis.   Journal of Infectious Disease Borges et al. on behalf of the Strategies for Management of Antiretroviral Therapy (SMART) and Strategic Timing of AntiRetroviral Treatment (START) studies aimed to quantify the relative difference between deferred/intermittent antiretroviral therapy (ART) and immediate/continuous ART […]
Hampel et al., Chemsex drugs in the Swiss HIV Cohort Study
Chemsex drugs on the rise: a longitudinal analysis of the Swiss HIV Cohort Study from 2007 to 2017.   HIV Medicine Hampel et al. aimed to analyse the trend in the consumption of all recreational drugs over the last 11 years among all participants in the Swiss HIV Cohort Study (SHCS), with a particular focus on […]
Santos et al., Deficit neurocongnitivi nei pazienti della SHCS
Penetrazione dei farmaci antiretrovirali nel sistema nervoso centrale e deficit neurocongnitivi nei pazienti della SHCS I deficit neurocognitivi (disturbi della memoria, deficit dell’attenzione, problemi nella presa di decisione) sono frequenti nelle persone con infezione da HIV. A seconda degli strudi tra 25 e 70% delle persone sieropositive soffre di tali deficit. Un fattore che favorisce […]
Santos et al., Neurokognitive Beeinträchtigungen bei Patienten aus der Schweizerischen HIV Kohortenstudie
Penetration der antiretroviralen Substanzen in das Zentralnervensystem und neurokognitive Beeinträchtigungen bei Patienten aus der Schweizerischen HIV Kohortenstudie Neurokognitive Einschränkungen (Gedächtnisstörungen, Aufmerksamkeitsdefizite, Probleme bei Entscheidungsfindungen) sind bei HIV-positiven Personen häufig. Studien schätzen deren Vorkommen in dieser Personengruppe auf 25 bis 70 Prozent. Ein Faktor, welcher das Auftreten von neurokognitiven Einschränkungen begünstigt, ist die unkontrollierte Vermehrung von […]
Santos et al., Déficits neurocognitifs chez les patients de la SHCS
Pénétration des substances antirétrovirales dans le système nerveux central et déficits neurocognitifs chez les patients de la SHCS Les déficits neurocognitifs (troubles de la mémoire, déficit d’attention, problème de prise de décision) sont fréquents chez les personnes infectées par le VIH. Selon des études 25 à 70% des séropositifs en sont touchés. Un facteur qui […]
Christe et al., Imaging PJP in HIV-pos and renal transplant patients
Imaging patterns of Pneumocystis jirovecii pneumonia in HIV-positive and renal transplant patients – a multicentre study. Â Â Swiss Medical Weekly Christe et al. aimed to explore the computed tomography (CT) and chest X-ray (CXRs) imaging features of Pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients from two well-defined cohorts, the Swiss HIV Cohort Study (SHCS) and […]
Courlet et al., Pharmacokinetic profiles of antiretroviral drugs in the aging population
Pharmacokinetic profiles of boosted darunavir, dolutegravir and lamivudine in aging patients enrolled in the Swiss HIV Cohort Study.   AIDS Courlet et al. aimed to compare boosted darunavir, dolutegravir, and lamivudine plasma exposures between aging (≥ 65 years) and younger (< 65 years) people living with HIV (PLWH) involved in two observational studies to better […]