Greenberg et al., Uptake and discontinuation of INSTIs
Uptake and discontinuation of integrase inhibitors (INSTIs) in a large cohort setting. Â Â JAIDS Greenberg et al. on behalf of the RESPOND Study Group aimed to describe the characteristics of patients initiating integrase strand transfer inhibitors (INSTIs) for the first time in heterogeneous real-world settings across Europe and Australia. In this analysis, RESPOND participants starting […]
Glass et al., Asymptomatic HIV and clinical outcomes
The role of HIV asymptomatic status when starting ART on adherence and treatment outcomes and implications for test and treat: the Swiss HIV Cohort Study.  Clinical Infectious Disease Glass et al. aimed to assess trends in starting antiretroviral therapy (ART) over time and the potential impact of symptom status at ART initiation on adherence and […]
COVID-19 und HIV
Die SHCS bekommt mehr und mehr Anfragen wegen COVID-19 von Menschen mit HIV. Zurzeit gibt es keine Evidenz, dass Menschen mit HIV ein höheres Risiko haben, an SARS-CoV-2 schwerer zu erkranken als andere. Es gelten deshalb die gleichen Risikofaktoren wie für die Gesamtbevölkerung. Die hauptsächlichen Risikofaktoren schwerer zu erkranken sind, Höheres Alter (> 65 Jahre) […]
Pantazis et al., Determining the likely place of HIV acquisition for migrants in Europe
Determining the likely place of HIV acquisition for migrants in Europe combining subject-specific information and biomarkers data.   Statistical Methods in Medical Research Pantazis et al. aimed to propose a method to derive subject-specific estimates of unknown HIV infection times among migrants in Europe using information from HIV biomarkers’ measurements, demographic, clinical, and behavioral data. […]
Ryom et al., CKD disease burden in HIV-positive persons
Serious clinical events in HIV-positive persons with chronic kidney disease (CKD). Â Â AIDS Ryom et al. on behalf of the D:A:D study group aimed to investigate the disease spectrum and the prognosis after a diagnosis of chronic kidney disease (CKD) stage G3+ in people living with HIV (PLWH) with focus on the incidence of serious […]
Courlet et al., Drug-drug interactions in people living with HIV
Polypharmacy, drug-drug interactions, and inappropriate drugs: New challenges in the aging population with HIV.   Open Forum Infectious Disease Courlet et al. aimed to compare prescribed medications, polypharmacy, and potential drug–drug interactions (DDIs) between young and elderly people with HIV (PWH) included in 2 centers of the Swiss HIV Cohort Study (SHCS). PWH from 2 centers […]
Ryom et al., Use of contemporary protease inhibitors and risk of incident chronic Kidney disease in persons with HIV
Use of contemporary protease inhibitors and risk of incident chronic Kidney disease in persons with human immunodeficiency virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study. Â Journal of Infectious Diseases Ryom et al. on behalf of the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study aimed to assess whether […]
Vannappagari et al., Tasso di malformazione nei neonati dopo trattamento con dolutegravir durante la gravidanza
Tasso di malformazione nei neonati dopo trattamento con dolutegravir durante la gravidanza.   Journal of Acquired Immune Deficiency Syndrome Dolutegravir fa parte delle sostanze anti-HIV prescritte più frequentemente su scala mondiale. Uno studio precedente fatto in Africa (Botswana) ha mostrato che le donne sotto trattamento con dolutegravir al momento della concezione erano soggette ad un […]
Vannappagari et al., Fehlbildungsraten unter Dolutegravir in der Schwangerschaft
Fehlbildungsraten unter Dolutegravir in der Schwangerschaft.   Journal of Acquired Immune Deficiency Syndrome Der Integrasehemmer Dolutegravir ist eine der am häufigsten eingesetzten HIV-Substanzen weltweit. In einer früheren Studie in Botswana/Afrika fanden sich Hinweise, dass Dolutegravir bei den Neugeborenen von Frauen, welche zum Zeitpunkt der Empfängnis unter Dolutegravir standen, eine erhöhte Rate an Rückenmarksfehlbildungen hervorgerufen hat. […]
Rodger et al., HIV transmission through condomless sex in serodifferent gay couples
Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study. Â Lancet The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) […]