Compagno et al., MTCT of antiretroviral drug-resistant HIV strains is low
The rate of mother-to-child transmission of antiretroviral drug-resistant HIV strains is low in the Swiss Mother and Child HIV Cohort Study. Swiss Medical Weekly Combination antiretroviral therapy (cART) has reduced mother-to-child transmissions (MTCT) and improved the prognosis of HIV-infected newborns. However, drug resistance mutations (DRM) in HIV-infected children, either transmitted by MTCT (HIV-tDRM) or […]
Amele et al., Establishing HCV CoC in HIV-positive individuals
Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA. HIV Medicine Amele et al. within EuroSIDA assessed how many patients in a given population are hepatitis C positive, have a replicating HCV infection (HCV-RNA positive), receive treatment and are cured is of importance (also called the continuum of care). […]
Barcelo et al., Dolutegravir population pharmacokinetics
Population pharmacokinetics of dolutegravir: influence of drug-drug interactions in a real-life setting. Journal of Antimicrobial Chemotherapy Dolutegravir is widely prescribed owing to its potent antiviral activity, high genetic barrier and good tolerability. Barcelo et al. within the SHCS characterized dolutegravir’s pharmacokinetic profile and variability in a real-life setting and identified individual factors and co-medications […]
Kovari et al., Antiretroviral drugs associated with subclinical CAD in the SHCS
Antiretroviral drugs associated with subclinical coronary artery disease in the Swiss HIV Cohort Study. Clinical Infectious Disease. The question whether certain antiretroviral drugs are associated with coronary artery disease (CAD) is of importance and some associations have been identified over the years. However, the influence of ART on subclinical atherosclerosis is not clear. Kovari […]
Wandeler et al., Incidence of HCC in HIV/HBV-coinfected patients on tenofovir
Incidence of hepatocellular carcinoma in HIV/HBV-coinfected patients on tenofovir therapy: Relevance for screening strategies. Journal of Hepatology Wandeler et al., in a collaboration of the SHCS, ATHENA, ANRS CO3 Aquitaine Cohort and EUROSIDA performed a study on screening strategies for hepatocellular carcinoma (HCC) in HIV/HBV co-infected patients on antiretroviral treatment. For this high quality HCC […]
Hachfeld et al., Why do Africans present late for Swiss HIV care?
Why do sub-Saharan Africans present late for HIV care in Switzerland? HIV Medicine Late presentation (LP) to care of HIV-1 infected individuals remains a problem, although for many years now it is clear that early initiation of antiretroviral therapy is highly beneficial for the individual but also on the population level. Hachfeld et al. […]
Carlisle et al., Time since infection from HIV diversity
Viral diversity from next-generation sequencing of HIV-1 samples provides precise estimates of infection recency and time since infection. Journal of Infectious Disease To determine the accurate time of an HIV-1 infection is often very difficult respectively impossible because of a lack of negative HIV-testing, lack of symptoms of an acute retroviral syndrome or a […]
Caniglia et al., Emulating a trial monitoring treatment HIV
Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals. Statistics in Medicine. Caniglia et al. from the HIV-Causal collaboration performed a study emulating a clinical trial investigating the question whether monitoring frequency could be lowered. Decisions about when to start or switch a therapy often depend on […]
Barido-Sottani et al., Detection of HIV transmission clusters from phylogenetic trees
Detection of HIV transmission clusters from phylogenetic trees using a multi-state birth-death model. Journal of the Royal Society Interface. The Swiss HIV Cohort Study (SHCS) for many years uses phylogenetic methods to better understand transmission of HIV to ultimately improve public health interventions. Barido-Sottani et al., a collaborating group from ETHZ/BSSE Basel, developed a […]
Abela et al., Analysis of ADR in the Swiss HIV Cohort Study
Emergence of drug resistance in the Swiss HIV Cohort Study under potent antiretroviral therapy is observed in socially disadvantaged patients. Clinical Infectious Disease In the Swiss HIV Cohort Study, the rate of acquired drug resistance (ADR) has fallen dramatically since introduction of combined antiretroviral therapy (ART). To further identify, why some people still fail […]