Swiss HIV Cohort Study

Hachfeld et al., Perché la diagnosi di infezione HIV è posta tardivamente nelle persone originarie dall’Africa sub-sahariana?

Perché la diagnosi di infezione HIV è posta tardivamente nelle persone originarie dall’Africa sub-sahariana?    HIV Medicine Spesso le infezioni da HIV nei pazienti originari dell’Africa sub-sahariana sono diagnosticate in uno stadio avanzato. Un’infezione è diagnosticata tardivamente quando il numero di linfociti CD4+ è basso e/o vi è una malattia tipica dell’AIDS. Gli autori di […]

Nguyen et al., HLA-B homogeneity within HIV phylogeny

HIV transmission chains exhibit greater HLA-B homogeneity than randomly expected.    JAIDS HIV’s capacity to escape immune recognition by Human Leukocyte Antigen (HLA) is a core component of HIV pathogenesis. A better understanding of the distribution of HLA Class I in HIV-infected patients would improve our knowledge of pathogenesis in relation to host HLA type, […]

Hachfeld et al., Warum werden Personen aus Subsahara-Afrika mit einer HIV-Infektion spät diagnostiziert?

Warum werden Personen aus Subsahara-Afrika mit einer HIV-Infektion spät diagnostiziert?   HIV Medicine HIV-Infektionen werden bei Patienten aus Subsahara-Afrika oft in einem späten Stadium diagnostiziert. Eine spät diagnostizierte Infektion ist definiert durch eine tiefe CD4-Zell Zahl und/oder AIDS-definierenden Erkrankungen. Die Autoren dieser Studie haben die Gründe dieser Beobachtung in der Schweizerischen HIV Kohortenstudie untersucht. Sie […]

Hachfeld et al., Pourquoi le diagnostic d’une infection par le VIH est-il posé tardivement chez les personnes originaires d’Afrique subsaharienne?

Pourquoi le diagnostic d’une infection par le VIH est-il posé tardivement chez les personnes originaires d’Afrique subsaharienne?   HIV Medicine Fréquemment, les infections par le VIH chez les patients d’Afrique subsaharienne sont diagnostiquées à un stade avancé. Une infection diagnostiquée tardivement se définie par un nombre de cellules CD4 bas et/ou des maladies révélatrices du […]

Bailey et al., NRTI backbones and pregnancy outcomes

Nucleoside reverse transcriptase inhibitor backbones and pregnancy outcomes.    AIDS The aim of the study of the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) with MoCHIV was to investigate whether specific nucleoside reverse transcriptase inhibitor (NRTI) backbones are associated with risk of adverse pregnancy outcomes among pregnant women starting antiretroviral therapy (ART). For this […]

Salazar-Vizcaya et al., Dissimilar trends in sexual behavior

Clusters of sexual behaviour in HIV-positive men who have sex with men reveal highly dissimilar time trends.    Clinical Infectious Diseases To understand behavioural patterns it is probably key to interfere successfully with the global increase in sexually transmitted diseases. Separately addressing specific groups of people who share patterns of behavioural change might increase the […]

Courlet et al., Emtricitabine and lamivudine concentrations in saliva

Emtricitabine and lamivudine concentrations in saliva: a simple suitable test for treatment adherence.    Journal of Antimicrobial Chemotherapy ART constitutes the cornerstone of HIV treatment and prevention. Successful ART results in suppressed viral load (VL) levels. Courlet et al. tested whether non-invasive saliva sampling could represent an alternative or clinically useful addition to VL measurements […]

Dietrich et al., Genetics of chronic Kidney disease in HIV

Contribution of genetic background and clinical D:A:D risk score to chronic kidney disease in Swiss HIV-positive persons with normal baseline estimated glomerular filtration rate.    Clinical Infectious Disease In HIV, the relative contribution of genetic background, clinical risk factors, and antiretrovirals to chronic kidney disease (CKD) is unknown. Dietrich et al. applied a case-control design […]

Collins et al., Switch to second-line ART in children with HIV

Incidence of switching to second-line antiretroviral therapy and associated factors in children with HIV: an international cohort collaboration.    Lancet HIV Estimates of incidence of switching to second-line antiretroviral therapy (ART) among children with HIV are necessary to inform the need for paediatric second-line formulations. They aimed to quantify the cumulative incidence of switching to […]

Gras et al., Immunological restoration during suppressive ART

Determinants of restoration of CD4 and CD8 cell counts and their ratio in HIV-1-positive individuals with sustained virological suppression on antiretroviral therapy.    Journal of Acquired Immune Deficiency Syndrome. Restoration of CD4 cell counts and normalization of CD8 cell counts is one major goal of antiretroviral therapy. Over the last years, an increasing number of […]