Bouatou et al., Lipodystrophy and chronic kidney disease in patients with HIV
Lipodystrophy increases the risk of CKD development in HIV-positive patients in Switzerland: The LIPOKID Study. Kidney International Reports Bouatou et al. aimed to test the hypothesis that lipodystrophy syndrome (LD) is independently associated with the development of chronic kidney disease (CKD), as defined by an eGFR Among the 5’384 patients included, 1’341 (24.9%) developed LD […]
Bibert et al., IFNL3/4 polymorphism and Kaposi’s sarcoma
IFNL3/4 polymorphisms are associated with AIDS-related Kaposi’s sarcoma. AIDS Bibert et al. aimed to analyze whether single nucleotide polymorphisms (SNPs) within the Interferon lambda 3/4 region (IFNL3/4) variants are associated with susceptibility to AIDS-related Kaposi’s sarcoma among men who have sex with men (MSM) enrolled in the Swiss HIV Cohort Study. Of note, SNPs encoding […]
Pettit et al., Increased non-AIDS mortality among persons with AIDS-defining events after ART initiation
Increased non-AIDS mortality among persons with AIDS-defining events after antiretroviral therapy initiation. Journal of the International AIDS Society Pettit et al. for the Antiretroviral Therapy Cohort Collaboration investigators aimed to estimate the overall effect of AIDS-defining events (ADEs) on the risk of non-AIDS-defining events (NADE) mortality after antiretroviral therapy (ART) initiation in high-income settings. The […]
Satta et al., Anti-apolipoprotein A1 IgG in HIV patients
Anti-apolipoprotein A-1 autoantibodies are associated with immunodeficiency and systemic inflammation in HIV patients. Journal of Infection. Journal of Infection Satta et al. aimed to determine the existence of autoantibodies against apolipoproteinA-1 (anti-apoA-1 IgG) in HIV patients and explore their association with biological features of HIV infection and different inflammatory biomarkers. So far, anti-apoA-1 IgG […]
Roen et al., Abacavir and hypersensitivity reactions
Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort. HIV Medicine Roen et al. on behalf of the EuroSIDA study aimed to describe the proportion of individuals initiating abacavir (ABC) and to describe the incidence and factors associated with hypersensitivity reactions (HSR) among those prescribed ABC. Between 2009 and 2016, of 10’076 individuals […]
Kouyos et al., ‘L’empreinte digitale’ des anticorps VIH-1
‘L’empreinte digitale’ des anticorps VIH-1. Nature Seul peu de personnes infectées par le VIH-1 développent des anticorps dits «neutralisants à large spectre (bnAbs)» qui visent certaines structures du virus (antigènes) et de ce fait sont capables de neutraliser différentes variantes du virus. Les facteurs qui déterminent si une personne développe des bnAbs ou non […]
Adland et al., HLA-B*27:02-mediated control of HIV-1
Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05- and -B*27:02-mediated control of HIV-1 infection. Journal of Virology The association between HLA-B*27:05 and protection against HIV disease progression in untreated HIV-seropositive individuals has been linked to immunodominant HLA-B*27:05- restricted CD8* T-cell responses toward the conserved Gag KK10. In this study, Adland et al. aimed […]
Kouyos et al., “L’impronta digitale” degli anticorpi anti-HIV-1
“L’impronta digitale” degli anticorpi anti-HIV-1. Nature Poche persone con infezione da HIV-1 sviluppa degli anticorpi detti “neutralizzanti a largo spettro” (bnAbs), che sono indirizzati contro determinate strutture virali (antigeni) e che sono capaci di neutralizzare differenti varianti del virus. I fattori che determinano se una persona sviluppa o meno dei bnAbs non sono conosciuti. […]
Kouyos et al., Der „HIV-1 Antikörper-Fingerabdruck”
Der „HIV-1 Antikörper-Fingerabdruck”. Nature Nur wenige Menschen, die mit HIV-1 infiziert sind, entwickeln sogenannte breit neutralisierende Antikörper (bnAbs), die auf bestimmte Virusstrukturen (Antigene) zielen und somit verschiedene Virusvarianten neutralisieren können. Die Faktoren, welche bestimmen, ob jemand bnAbs entwickelt, sind nicht völlig klar; insbesondere ist der Beitrag der Virusmerkmale unbekannt. Die Identifizierung der Virusmerkmale für eine […]
Naret et al., Population stratification correction in genome-to-genome analysis
Correcting for population stratification reduces false positive and false negative results in joint analyses of host and pathogen genomes. Frontiers in Genetics Multiple genome-wide association studies (GWAS) of clinical outcomes have identified human genetic variants that play a modulating role in infectious diseases. To explore the potential impact of human genetic diversity on infection, […]