Blanquart et al., Viral genetic variation explains variability in HIV-1 pathogenesis
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe. PLoS Biology Current estimates of HIV-1 set-point viral load (SPVL) heritability vary widely in literature, from 6% to 59%. Blanquart et al. on behalf of the BEEHIVE collaboration used a dataset of 2,028 seroconverters from 5 European countries […]
Beauparlant et al., Delineating CD4 dependency of HIV-1
Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality. PLoS Pathogens A hallmark of HIV-1 infection is the continuously declining number of the virus’ predominant target cells, activated CD4+ T cells. With diminishing CD4+ T cell levels, the capacity to […]
Béguelin et al., Hepatitis D bedingte Sterblichkeit bei HIV/Hepatitis B koinfizierten Personen
Hepatitis D bedingte Sterblichkeit bei HIV/Hepatitis B koinfizierten Personen. Journal of Hepatology Den meisten Personen ist bekannt, dass die drei Virusinfektionen HIV, Hepatitis C und Hepatitis B weltweit bedeutend sind aufgrund ihres häufigen Vorkommens und jedes Jahr viele Millionen Menschen an den Folgen dieser Virusinfektionen sterben. Weniger gut ist jedoch bekannt, dass auch […]
Achhra et al., Impact of early versus deferred ART on eGFR rate
Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial. International Journal of Antimicrobial Agents The START trial is a randomised controlled clinical trial of immediate initiation of antiretroviral therapy (ART) (‘immediate’ arm) versus deferral of ART initiation until CD4+ counts decline to <350 cells/mm3 […]
Béguelin et al., Mortalité liée à l’hépatite D chez les personnes avec une co-infection VIH/hépatite B
Mortalité liée à l’hépatite D chez les personnes avec une co-infection VIH/hépatite B. Journal of Hepatology Les trois infections virales VIH, hépatite C et hépatite B sont un enjeu mondial à cause de leur importante prévalence et parce que chaque année des millions de personnes décèdent des suites de ces infections. Ce que l’on […]
Béguelin et al., Mortalità associata all’epatite delta nelle persone con una co-infezione HIV/epatite B
Mortalità associata all’epatite delta nelle persone con una co-infezione HIV/epatite B. Journal of Hepatology Le tre infezioni virali HIV, epatite C ed epatite B rappresentano una sfida a livello mondiale a causa dell’elevata prevalenza per cui ogni anno milioni di persone muoiono come conseguenza di queste malattie. Oggi sappiamo che il virus dell’epatite delta (o […]
Bachmann et al., Heritability of an HIV 1 trait in a realistic setup
Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup. Retrovirology Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO regression to viral traits is unclear because the direction […]
Chereau et al., Loss of virological control among HIV controllers
Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers. PLoS One Chereau et al. on behalf of the HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCOORD aimed to identify factors associated with loss of virological control among HIV […]
Bertels et al., Dissecting HIV virulence
Dissecting HIV virulence: heritability of setpoint viral load, CD4+ T cell decline and per-parasite pathogenicity. Molecular Biology and Evolution The ability of pathogens to evoke virulence by different diseases-causing mechanisms independent of their load refers to as ”per-parasite pathogenicity”. Using viral load and CD4+ T cell measures from 2’014 HIV-1 subtype B infected individuals enrolled […]
Bayard et al., Avascular necrosis in HIV
Associations between antiretroviral treatment and avascular bone necrosis: The Swiss HIV Cohort Study. Open Forum Infectious Diseases. Bayard et al. aimed to study the associations of antiretroviral therapy (ART) with the occurrence of avascular bone necrosis (AVN) among Swiss HIV Cohort Study participants. For each case with confirmed AVN, they randomly selected SHCS participants […]