Labarile et al., Untarget metabolite profile associations with BMI, waist-hip ratio and ART in PWH
Untargeted Metabolite profile associations with Body Mass Index, waist-hip ratio, and antiretroviral therapy in >1300 people with HIV: the Swiss HIV Cohort Study Labarile et al. analyzed the metabolic profiles of 1ā302 people with HIV (PWH) in Switzerland to understand how obesity and different antiretroviral therapies (ART) are linked to changes in blood metabolites. The […]
Abela et al., Differenze di genere nella prescrizione di statine a persone affette da HIV e con rischio basso/medio-alto di malattie cardiovascolari
Differenze di genere nella prescrizione di statine a persone affette da HIV e con rischio basso/medio-alto di malattie cardiovascolari. Grazie ai farmaci moderni, oggi le persone affette da HIV hanno un’aspettativa di vita simile a quella delle persone sieronegative. Tuttavia, permane un rischio piĆ¹ elevato di malattie cardiovascolari, come infarto o ictus. I farmaci, come […]
Abela et al., DiffĆ©rences de genre dans la prescription de statines chez les personnes vivant avec le VIH prĆ©sentant un risque faible/moyen Ć Ć©levĆ© de maladies cardiovasculaires
DiffĆ©rences de genre dans la prescription de statines chez les personnes vivant avec le VIH prĆ©sentant un risque faible/moyen Ć Ć©levĆ© de maladies cardiovasculaires. GrĆ¢ce aux mĆ©dicaments modernes, les personnes vivant avec le VIH ont aujourd’hui une espĆ©rance de vie similaire Ć celle des personnes ne vivant pas avec le VIH. Elles prĆ©sentent nĆ©anmoins un […]
Abela et al., Geschlechtsspezifische Unterschiede bei der Verschreibung von Statinen bei Menschen mit HIV und niedrigem/mittlerem bis hohem Risiko fĆ¼r Herzkreislauferkrankungen
Geschlechtsspezifische Unterschiede bei der Verschreibung von Statinen bei Menschen mit HIV und niedrigem/mittlerem bis hohem Risiko fĆ¼r Herzkreislauferkrankungen. Menschen mit HIV haben heute dank moderner Medikamente eine Ƥhnliche Lebenserwartung wie Menschen ohne HIV. Trotzdem haben sie ein hƶheres Risiko fĆ¼r Herz-Kreislauf-Erkrankungen, wie Herzinfarkte oder SchlaganfƤlle. Medikamente wie Statine, welche zur Cholesterinsenkung eingesetzt werden, kƶnnen dieses […]
Audige et al., SARS-CoV-2 T-cell assay agreement
Low agreement between SARS-CoV-2 T-cell assays in immunocompromised individuals T-cell responses are an important component of immunity against SARS-CoV-2, especially in people with compromised immune systems where antibody responses may be suboptimal. Commercial interferon-Ī³ release assays (IGRAs) have become available to measure SARS-CoV-2āspecific T-cell responses, but their reliability in such populations remains uncertain. AudigĆ© and […]
Harney et al., Unsuccessful DAA HC treatment among PWH
Unsuccessful direct-acting antiviral Hepatitis C treatment among people with HIV: Findings from an international cohort Ā Successful treatment of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) is now expected in almost all people with HIV (PWH). However, a small proportion still do not achieve cure, and understanding the reasons for unsuccessful treatment remains important […]
Schoepf et al., Longitudinal time trends of LTFs in PWH
In the present study, Schoepf et al investigated time trends of low trauma fractures in people with HIV. The authors benefited from the standardized data collection on fractures in the SHCS, which is implemented since 2008. They estimated low trauma fractures incidence rates per calendar year from 2009 to 2022 and adjusted for clinical and […]
Zeeb et al., Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1
Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1 This week we highlight the study by Zeeb et al., published in PLOS Pathogens, which offers new insights into how latent tuberculosis (TB) infection shapes the immune response to HIV. This work builds on the long-standing contributions of the Swiss HIV Cohort Study (SHCS), which […]
Hesselmann et al., Rare twin cysteine residues in HIV-1 Env and neutralization breadth
Rare twin cysteine residues in HIV-1 Env and neutralization breadth Ā This week we highlight the study by Hesselman et al., published in Cell Host & Microbe and awarded the SSI Award in Basic Research, titled āRare twin cysteine residues in HIV-1 Env and neutralization breadth.ā Broadly neutralizing antibodies (bnAbs) against HIV-1 typically target the viral […]
Baumann et al., Evoluzione a lungo termine delle infezioni da epatite C, dei loro trattamenti e delle complicazioni nello Studio svizzero di coorte HIV
L’epidemia in via di estinzione ā Evoluzione a lungo termine delle infezioni da epatite C, dei loro trattamenti e delle complicazioni nello Studio svizzero di coorte HIV Le infezioni da virus dellāepatite C causano malattie epatiche e decessi in tutto il mondo. Le persone che vivono con un’infezione da HIV sono particolarmente a rischio di […]