Algorithm evolution for drug resistance prediction: comparison of systems for HIV-1 genotyping. Antiviral Therapy
Wagner et al. assessed the concordance of the three genotypic HIV-1 drug resistance interpretation algorithms ANRS, Rega and Stanford-HIVdb and their evolution over time. The algorithm versions of 2004 on the analyzed sequences classified 55% of viruses as resistant to at least one antiretroviral drug compared to 63% when the 2013 version was used. Discordant results were obtained for 24% of all samples with the 2004 version compared to 26% of samples with the 2013 version. Most deviations reflected differences between the ANRS and the other two algorithms.
The study results emphasize the need for further adjustment and improvement of the existing interpretation algorithms.