The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals. AIDS
Kohler et al. investigated the impact of influenza vaccination and HIV-disease parameters on the breadth and magnitude of antibody responses in HIV-infected individuals. They found that both homo and heterosubtypic antibody titers were lower in HIV-positive individuals. Vaccination increased homosubtypic but had no impact on heterosubtypic serum antibodies. There was no HIV-related parameter that could be used as reliable predictor for the breadth or magnitude of the humoral response to influenza A viruses.
The results clearly support the importance of vaccination of HIV-infected individuals against influenza viruses.