Contribution of genetic background and clinical risk factors to low-trauma fractures in HIV-positive persons: The Swiss HIV Cohort Study. Open Forum Infectious Diseases
Junier et al. aimed to quantitate the contribution of 6 common single-nucleotide polymorphisms (SNPs) to the risk of low-trauma fracture (LTF) in HIV-positive participants enrolled in the Swiss HIV Cohort Study (SHCS). In multivariable analysis, LTF risk was associated with height, corticosteroids, and smoking. Of note, weight, CD4 nadir, HCV coinfection, alcohol, injection drug use, cumulative exposure to tenofovir disoproxil fumarate, and protease inhibitors were not associated with LTF risk. In the multivariable model that included genetic background, the additive genetic score built from the 6 LTF-associated SNPs was not associated with LT.
The study-results suggest that genetic testing is presently not a useful predictor or monitoring tool for bone health in HIV.