Sex differences in overall and cause-specific mortality among HIV-infected adults on antiretroviral therapy in Europe, Canada and the US. Antiviral Therapy
Jarrin et al. on behalf of the Antiretroviral Therapy Cohort Collaboration, examined differences in rates among men and women infected through heterosexual intercourse or injecting drug use treated with combination antiretroviral therapy in Europe and North America. Comparing women and men in Europe, all-cause mortality hazard ratio (HR) was 0.76 after adjustment for prognostic factors at baseline. The HR was similar for AIDS-related mortality but significantly lower for non-AIDS related mortality in European women compared to European men. By contrast, there was little evidence of between-sex differences in all-cause or cause-specific mortality in North America.
In conclusion, patterns of non-AIDS mortality (e.g. malignancies, cardiovascular diseases) in HIV-infected cohort members in Europe are coming to resemble those of the general population, and sex mortality ratios in treated HIV-positive people may increasingly resemble those in the general population.