Improvements over time in short-term mortality following myocardial infarction in HIV-positive individuals AIDS
Hatleberg et al. for the D:A:D study group evaluated changes in short-term mortality after myocardial infarction (MI) in HIV-positive individual. One thousand and eight D:A:D participants experienced an MI over the period 1999–2014. The absolute number of MIs decreased from 214 (1999–2002) to 154 (2011–2014). Over a median follow-up time of 42.7 months after their MI, 117 of the 1008 HIV-positive individuals (11.6%) experienced a further MI and 339 (33.6%) died. The proportion of individuals who died in the first month after MI dropped from 26.6% in 1999–2002 to 8.4% in 2011–2014. Predictors of decreased short-term mortality were higher CD4+ cell count, family history of cardiovascular disease, later year of MI and the receipt of antiplatelets, lipid lowering drugs, and invasive cardiovascular procedures.
In conclusion, this study demonstrates improvements in short-term survival after MI in HIV-positive individuals, which appeared to be largely driven by increased use of drug interventions and invasive cardiovascular procedures.