Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry. Antiviral Therapy
Guidi et al. aimed at characterizing the kinetics of vitamin D [25(OH)D] in HIV-infected individuals to define the influence of genetic and non-genetic factors on 25(OH)D levels and to optimize vitamin D supplementation. They found that vitamin D deficiency ([25(OH)D]<20ng/ml) was present in 58% of all individuals. Seasonality and BMI had the strongest effect on 25(OH)D endogenous production. Eleven percent of the inter-individual variability in 25(OH)D levels was explained by non-genetic covariates, and 1% by genetics. Optimal supplementation for severe vitamin D deficiency (<10ng/ml) was 300’000 IU 2/year. A single vitamin D supplementation of 300’000 IU 1/year was appropriate for individuals with mild deficiency (<20ng/ml), independently of the season.
In conclusion, the study-results allow implementing a strategy for vitamin D supplementation dependent on the level of deficiency.