Self-reported nonadherence to antiretroviral therapy as a predictor of viral failure and mortality: Swiss HIV Cohort Study. AIDS
Glass et al. determined the effect of nonadherence to antiretroviral therapy (ART) on virological failure and mortality in naïve individuals starting ART. Missing of two or more ART doses in the previous 4 weeks increased the risk of both viral failure and mortality. The risk of viral failure increased with each missed dose. Simplification to once-daily regimens was associated with an increased risk of viral failure compared to twice-daily regimens in the presence of nonadherence.
The study-results underscore the importance of regular investigation of adherence at each clinical visit.