Kovari et al., HCV und nicht leberbedingte Sterblichkeit
Die Hepatitis C Virus-Infektion und das Risiko der nicht leberbedingten Sterblichkeit in HIV-infizierten Menschen in der Schweizerischen HIV Kohortenstudie. Clinical Infectious Diseases Eine Hepatitis C Virus (HCV) Infektion bei HIV-infizierten Menschen ist häufig und betrifft bis zu 30% der HIV-infizierten Personen. Die chronische HCV-Infektion ist mit einer Vielzahl von nicht leberbedingten Erkrankungen vergesellschaftet wie […]
Abujaber et al., No association of β-defensin copy number and HIV
No evidence for association of β-defensin genomic copy number with HIV susceptibility, HIV load during clinical latency, or progression to AIDS. Annals of human genetics The role of gene copy number variation, where the number of copies of the same gene differs between individuals, in affecting clinical parameters of HIV infection is of interest. Previous […]
Trickey et al., Survival of HIV-positive patients starting ART between 1996-2013
Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV The Antiretroviral Therapy Cohort Collaboration aimed to examine changes in 3 year survival and life expectancy of patients starting combination antiretroviral therapy (ART) between 1996 and 2013. The study used data for 88’504 people […]
Shilaih et al., Factors associated with syphilis in the SHCS
Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine Shilaih et al. aimed to examine the factors that affect syphilis incidence in the Swiss HIV Cohort Study. The incidence rate was 26.8 cases per 1000 person-years for men who have sex with men (MSM), 1.3 for […]
Bartha et al., Host and viral genomic contribution to HIV control
Estimating the respective contributions of human and viral genetic variation to HIV control. PLoS Computational Biology Bartha et al. evaluated the fraction of variation in HIV-1 set point viral load (spVL) attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. On the host side, the […]
Trickey et al., Cause de décès des patients qui ont survécu dix ans de thérapie antirétrovirale
Cause de décès des patients qui ont survécu dix ans de thérapie antirétrovirale. PLoS One Les personnes séropositives qui ont commencé une thérapie anti-VIH peu après l’introduction du traitement combiné en 1996 sont aujourd’hui près de 20 ans sous traitement. Le taux de mortalité de ces séropositifs est d’un grand intérêt car ils ont […]
Trickey et al., Cause di decesso dei pazienti che hanno ricevuto almeno 10 anni di terapia antiretrovirale
Cause di decesso dei pazienti che hanno ricevuto almeno 10 anni di terapia antiretrovirale. PLoS One Le persone sieropositive che hanno iniziato una terapia anti-HIV poco dopo l’introduzione del trattamento combinato nel 1996 hanno assunto ad oggi un trattamento per 20 anni. Il tasso di mortalità di queste persone riveste un grande interesse essendo […]
Trickey et al., Todesursache von Patienten, welche zehn Jahre HIV-Therapie überlebt haben
Todesursache von Patienten, welche zehn Jahre HIV-Therapie überlebt haben. PLoS One HIV-positive Menschen, welche gleich nach Einführung der HIV-Kombinationstherapie 1996 mit einer HIV-Therapie begonnen haben, sind mittlerweile bis zu 20 Jahre mit HIV-Medikamenten behandelt. Die aktuelle Sterblichkeitsrate dieser HIV-infizierten Menschen ist von grossem Interesse, da sie über lange Zeit HIV-Medikamenten mit beträchtlichem Nebenwirkungspotential ausgesetzt […]
Marzel et al., Mining for transmission pairs
Mining for pairs: shared clinic visit dates identify steady HIV positive partnerships. HIV Medicine Marzel et al. examined the hypothesis that some stable HIV-infected partnerships can be found in cohort studies, as the patients frequently attend the clinic visits together. Their method to identify steady transmission pairs and serosorting couples was based on the intuition […]
Negoescu et al., Differentiated monitoring of HIV viral load
Differentiated HIV RNA viral load monitoring in resource-limited settings: an economic analysis. Clinical Infectious Diseases Negoescu et al. developed a mathematical model using person-level longitudinal data to personalize decisions for timing of viral load monitoring. Moreover, they performed a cost-effectiveness analysis to inform the optimal monitoring interval in different resource contexts. The authors compared the […]