Lodi et al., Immediate initiation of antiretroviral treatment
Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance.   AIDS Lodi et al. on behalf of the HIV-CAUSAL collaboration aimed to estimate and to compare the 7-year risks of acquired drug resistance under immediate antiretroviral therapy (ART) initiation and the previously recommended CD4+ cell count-based initiation strategies. The authors […]
Aebi-Popp et al., Post-treatment HCV antibody dynamics
Rapid decline of anti-HCV antibodies following early treatment of incident HCV infections in HIV-infected MSM. Â Â HIV Medicine Aebi-Popp et al. investigated HCV antibody level dynamics following an incident HCV infection in HIV-infected MSM with different clinical outcomes: treatment-induced sustained virological response (SVR), spontaneous clearance, and untreated HCV infection progressing to chronic infection. At baseline, […]
Borges et al., I medicamenti anti-HIV e il rischio di fratture ossee
I medicamenti anti-HIV e il rischio di fratture ossee in un grande studio osservazionale.  Clinical Infectious Diseases Alcuni medicamenti per l’HIV hanno un influsso negativo sul metabolismo delle ossa. Non è ancora chiaro se questo problema possa favorire le fratture ossee. Ricercatori di vari studi di coorte HIV europei si sono chinati sulla questione […]
Tarr et al., Subclinical coronary artery disease in Swiss HIV+ and HIV- persons
Subclinical coronary artery disease in Swiss HIV-positive and HIV-negative persons. Â European Heart Journal Tarr et al. aimed to compare the prevalence of subclinical atherosclerosis in HIV-positive and HIV-negative persons in Switzerland using coronary artery calcium (CAC)/computed tomography angiography (CCTA), and to assess associations between cardiovascular risk factors, HIV infection, and subclinical coronary artery disease. […]
Borges et al., HIV-Medikamente und das Risiko für Knochenbrüche
HIV-Medikamente und das Risiko für Knochenbrüche in einer grossen HIV-Beobachtungsstudie.   Clinical Infectious Diseases Es ist bekannt, dass gewisse HIV-Medikamente den Knochenstoffwechsel ungünstig beeinflussen können. Unbekannt ist, ob dies zu einem höheren Risiko für Knochenbrüche führen kann. Forscher aus verschiedenen europäischen HIV Kohortenstudien sind dieser Frage nachgegangen und haben die Faktoren untersucht, welche bei HIV-infizierten […]
Borges et al., Les médicaments anti-VIH et le risque de fractures des os
Les médicaments anti-VIH et le risque de fractures des os dans une grande étude d’observation.   Clinical Infectious Diseases Certains médicaments anti-VIH ont une influence négative sur le métabolisme des os. Mais nous ne savons pas si ceci amène à d’avantage de fractures osseuses. Des chercheurs de plusieurs études de cohortes VIH européennes se sont penchés […]
Rasmussen et al., Phylodynamics on networks
Phylodynamics on local sexual contact networks. Â Â PLOS Computational Biology Phylodynamic models are widely used in infectious disease epidemiology to infer the dynamics and structure of pathogen populations. However, these models generally assume that individual hosts contact one another at random, ignoring the fact that many pathogens spread through highly structured contact networks. In the […]
Prague et al., Dynamic models for estimating the effect of HAART on CD4 in observational studies
Dynamic models for estimating the effect of HAART on CD4 in observational studies: Application to the Aquitaine Cohort and the Swiss HIV Cohort Study. Â Â Biometrics Prague et al. aimed to estimate the effect of HAART on CD4 count using four dynamic models and compared estimates with those from a naive regression model. In […]
Nakagawa et al., Estimating number living with HIV in the United Kingdom
An epidemiological modelling study to estimate the composition of HIV-positive populations including migrants from endemic settings. Â AIDS Nakagawa et al. aimed to demonstrate a novel approach using a mathematical model with the United Kingdom (UK) as an example, to present key public health outputs on the national level, including the size of the undiagnosed […]
McLaren et al., Exome sequencing and HIV-1 control
Evaluating the impact of functional genetic variation on HIV-1 control.  Journal of Infectious Diseases Human genetic variation plays a large role in determining the outcome of HIV-1 infection. However, common, genome-wide genetic factors identified by genome-wide association studies can only explain up to 25% of the observed variability in HIV setpoint viral load. To assess […]