Thoueille et al., Concentrations and effectiveness of long-acting cabotegravir and rilpivirine
Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland.   The Lancet Regional Health – Europe Thoueille et al. analyzed the drug levels of participants from the Swiss HIV Cohort Study (SHCS) who received long-acting cabotegravir (CAB) and rilpivirine (RPV) after the approval in March 2022 in Switzerland. Drug concentrations […]
Alberto et al., Evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis
Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study.  Sexually Transmitted Infections Alberto et al. aimed to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti-Treponema pallidum (T. pallidum) IgG for the diagnosis of neurosyphilis […]
McLaren et al., Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Africa-specific human genetic variation near CHD1L associates with HIV-1 load.  Nature McLaren et al. assessed genetic factors that determine HIV-1 viral replication capacity among individuals of African descent. The authors performed a genome-wide association study including more than 3’800 individuals from the International Collaboration for the Genomics of HIV. This collaboration included individuals from 11 cohorts, […]
Schoepf et al., Subclinical coronary artery disease polygenic risk scores in HIV
Polygenic risk scores for prediction of subclinical coronary artery disease in persons with human immunodeficiency virus (HIV): The Swiss HIV Cohort Study.  Clinical Infectious Disease Schoepf et al. aimed to o investigate validated, coronary artery disease (CAD)-associated, intima-media thickness (IMT)-associated, and longevity-associated polygenic risk scores (PRSs) to subclinical coronary plaque in Swiss people with HIV (PWH), […]
Baumann et al., Long-term trends in HCV prevalence, treatment uptake and liver-related events in the SHCS
Long-term trends in hepatitis C prevalence, treatment uptake and liver-related events in the Swiss HIV Cohort Study.  Liver International Baumann et al. assessed trends in the prevalence of replicating hepatitis C virus (HCV) infection, the uptake of HCV treatment, and its impact on liver-related morbidity and mortality among people with HIV (PWH) and HCV […]
Begré et al., QHBsAg trajectories in persons with HIV on TDF-containing ART
Long-term quantitative hepatitis B surface antigen (HBsAg) trajectories in persons with and without HBsAg loss on tenofovir-containing antiretroviral therapy.  HIV Medicine Begré et al. aimed to evaluate long-term trajectories of quantitative hepatitis B surface antigen (qHBsAg) and HBV (hepatitis B virus) DNA levels in persons with HIV/HBV with and without HBsAg loss during tenofovir-containing antiretroviral […]
Paioni et al., Soppressione della viremia e aderenza al trattamento durante il periodo post parto nelle donne che vivono con l’HIV
Soppressione della viremia e aderenza al trattamento durante il periodo post parto nelle donne che vivono con l’HIV.  The Lancet Regional Health – Europe Dal 2018 le donne che vivono con l’HIV hanno una viremia non misurabile nel plasma e in Svizzera possono allattare se lo desiderano. In tal caso i controlli nel periodo post parto […]
Paioni et al., Unterdrückung der Viruslast und Therapietreue während der nachgeburtlichen Periode bei Frauen mit HIV
Unterdrückung der Viruslast und Therapietreue während der nachgeburtlichen Periode bei Frauen mit HIV.  The Lancet Regional Health – Europe Seit 2018 können Frauen mit HIV mit nicht nachweisbarer Viruslast in der Schweiz stillen, wenn sie dies wünschen. In diesen Fällen ist die Nachsorge nach der Geburt von entscheidender Bedeutung. Trotz unterdrückter Viruslast bei der Entbindung wurde […]
Loosli et al., HIV-1 drug resistance in people on dolutegravir-based ART
HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis. Lancet HIV Loosli et al. assessed risk factors for dolutegravir (DTG) resistance and patterns of drug resistance mutations (DRM) among people with HIV (PWH) and replicating HIV infection on DTG-containing antiretroviral therapy (ART). For this international collaboration, the authors combined data from […]
Paioni et al., Suppression de la charge virale et observance du suivi pendant la période postnatale chez les femmes vivant avec le VIH
Suppression de la charge virale et observance du suivi pendant la période postnatale chez les femmes vivant avec le VIH.  The Lancet Regional Health – Europe Depuis 2018, les femmes vivant avec le VIH dont la charge virale est indétectable peuvent allaiter en Suisse si elles le souhaitent. Dans ces cas, le suivi postnatal est […]