Swiss HIV Cohort Study

3.1 HIV related diseases and symptoms
3.1.1 HIV-related peripheral neuropathy
3.1.2 HIV-related myelopathy
3.1.3 Thrombocytopenia
3.1.4 Primary pulmonary hypertension
3.1.5 Lymphoid interstitial pneumonia
3.1.6 Unexplained weight loss
3.1.7 Fever without infectious cause
3.1.8 Diarrhea

3.2 Protozoal and helmintic diseases
3.2.1 Microsporidiosis
3.2.2 Toxoplasmosis retinitis
3.2.3 Visceral leishmaniasis
3.2.4 Extraintestinal strongyloidiasis

3.3 Fungal diseases
3.3.1 Oral candidiasis
3.3.2 Vulvovaginal candidiasis
3.3.3 Aspergillosis

3.4 Bacterial diseases
3.4.1 Pelvic inflammatory disease
3.4.2 Nocardiosis
3.4.3 Bacillary angiomatosis
3.4.4 Listeriosis
3.4.5 Rhodococcus equi disease

3.5 Viral diseases
3.5.1 Unusual manifestation of herpes zoster
3.5.2 Progressive outer retinal necrosis syndrome
3.5.3 Oral hairy leukoplakia

3.6 Neoplastic diseases
3.6.1 Cervical dysplasia
3.6.2 Hodgkin’s disease

3.1 HIV related diseases and symptoms

3.1.1 HIV-related peripheral neuropathy (database code PNP)

Clinical signs and symptoms of peripheral neuropathy, with/without electrophysiological documentation

AND no evidence for another etiology.

3.1.2 HIV-related myelopathy (database code MYE)

Clinical signs and symptoms of myelopathy, with electrophysiological or radiological documentation

AND no evidence for another etiology.

3.1.3 Thrombocytopenia (database code ITP)

Thrombocytes <100 x 109/l, determined on two occasions at least a month apart

AND no evidence for another etiology (e.g. infection, tumor, myelosuppressive drugs).

3.1.4 Primary pulmonary hypertension (database code PPH)

Elevation of systolic right ventricular pressure (RVSP) over right atrial pressure (RAP) of greater than 25 mmHg, measured by continuous wave Doppler echocardiography or pulmonary artery pressure (PAP) of greater than 20 mmHg, measured by right heart catheterisation

AND exclusion of pulmonary emboli by lung perfusion scan (^99mTC macroaggregated albumin particles) or on autopsy

AND exclusion of obstructive or restrictive pulmonary disease based on clinical examination and by pulmonary function tests

AND normal left ventricular function

AND no evidence of congenital or valvular heart disease, evaluated by two-dimensional echocardiography

AND no history of use of anorectic agents.

3.1.5 Lymphoid interstitial pneumonia (database code LIP)

Definitive diagnosis by histology

3.1.6 Unexplained weight loss >10% (database code WLO)

Baseline weight is the first documented weight measured after the diagnosis of HIV infection. Weight loss % is calculated by averaging two similar weights on consecutive occasions during follow-up and comparing this mean to baseline.

3.1.7 Fever without infectious cause (database code FEV)

>14 consecutive days,
OR
>15 days in 30 day period, with investigations done to explain fever being negative.

3.1.8 Diarrhea (database code DIA)

At least three stools of reduced consistency per day for >30 days without concurrent specific cause.

3.2 Protozoal and helmintic diseases

3.2.1 Microsporidiosis (database code MIC)

Definitive diagnosis by microscopy of stool, or from biopsy. Must have a reliable history of persistent diarrhea for >1 month.

date
from when diarrhea has persisted >1 month

AND stool specimen taken with positive result.

3.2.2 Toxoplasmosis retinitis * (database code TOR)

Definitive diagnosis by typical appearance,
AND positive specific PCR from acqueous humor
AND responds to toxo. treatment.

Presumptive diagnosis by typical appearance,
AND responds to toxo treatment (no CMV treatment at the same time).

_{* in the SHCS this diagnosis is considered as a C event}

3.2.3 Visceral leishmaniasis (database code LEI)

Definitive diagnosis by histology/microscopy, not from skin

3.2.4 Extraintestinal strongyloidiasis (database code EIS)

Definitive diagnosis by microscopy or histology

3.3 Fungal diseases

3.3.1 Oral candidiasis (database code STO)

Severe, florid, marked, plaques (pseudomembranous), extensive, involving palate, persistent OR recurrent

Include new diagnoses of pseudomembranous
OR recurrent episodes of erythematous oral candidiasis, that are treated,
AND no relation to concomitant OR previous antibiotic OR immunesuppressive therapy.

3.3.2 Vulvovaginal candidiasis (database code CVV)

Severe, florid, marked, plaques (pseudomembranous), persistent or recurrent

Include new diagnoses of pseudomembranous,
OR recurrent episodes of erythematous candidiasis, that are treated,

AND no relation to concomitant or previous antibiotic
OR immunesuppressive therapy.

3.3.3 Aspergillosis (database code ASP)

Definitive diagnosis by culture of normally sterile site OR culture from sputum/BAL,

AND histology of invasive aspergillosis

3.4 Bacterial diseases

3.4.1 Pelvic inflammatory disease (database code PID)

Clinical diagnosis with further evidence by laparoscopy or (vaginal) ultrasonography.

3.4.2 Nocardiosis (database code NOC)

Definitive diagnosis by culture

3.4.3 Bacillary angiomatosis (database code BAN)

Definitive diagnosis by histology AND bacilli in modified silver stain positive PCR-test for Bartonella henselae

OR culture from tissue or blood.

3.4.4 Listeriosis (database code LIS)

By culture from blood, from CSF or from biopsy of normally sterile site,

OR by detection of antigen from CSF.

3.4.5 Rhodococcus equi disease (database code ROD)

Definitive diagnosis by culture

3.5 Viral diseases

3.5.1 Unusual manifestation of herpes zoster : multidermatomal or relapse (database code HZO)

Involving at least two dermatomes (contiguous or discontiguous),
or two distinct episodes.

3.5.2 Progressive outer retinal necrosis syndrome (database code POR)

Definitive diagnosis by typical appearance,
AND positive specific PCR from acqueous humor
AND responds to VZV treatment.

Presumptive diagnosis by typical appearance,
AND responds to VZV treatment

3.5.3 Oral hairy leukoplakia (database code OLP)

Extensive, marked, symptomatic or bilateral, or persistent.

3.6 Neoplastic diseases

3.6.1 Cervical dysplasia, carcinoma in situ (database code CDC)

Definitive diagnosis by histology. Include moderate or severe dysplasia or carcinoma in situ (CIN2 or 3).

3.6.2 Hodgkin’s disease (database code MHO)

Definitive diagnosis by histology

date
from date of biopsy or time of good evidence of the presence of a mass (by scan) which under biopsy shows Hodgkin’s lymphoma

Presumptive diagnosis not accepted