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Yang et al., Transmitted HIV-1 drug resistance mutations and fitness costs

23rd March, 2015

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds. PLoS Pathogens

Yang et al. assessed the role of fitness cost and the genetic background for resistance in vivo by studying the persistence behavior of transmitted antiretroviral resistance mutations of HIV in 857 sequential samples from the SHCS. They found that the reversion rate of individual mutations varied substantially and were positively associated with the fitness costs these mutations had in their genetic background.

PubMed

Swiss HIV Cohort Study

The Swiss HIV Cohort Study (SHCS), established in 1988, is a nationwide prospective longitudinal cohort study enrolling persons with HIV in Switzerland. It is a collaboration of all Swiss university hospitals, large cantonal hospitals with affiliated laboratories, and affiliated smaller hospitals and private physicians caring for persons with HIV.

The overarching aim of the SHCS is to improve health of persons living with HIV through clinical, translational and basic science studies, and to strengthen collaborative and transdisciplinary research.

The Swiss Mother and Child HIV Cohort Study (MoCHiV) is integrated into the SHCS. It aims at preventing mother-to-child transmission and enrolls pregnant women with HIV and their children.

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