Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study. AIDS Research and Therapy
Carballo et al. determined whether HIV infection is a risk factor for worse outcomes in patients with coronary artery disease (CAD). After adjustment for several traditional CAD risk-factors they found that HIV-positive individuals with a first episode of acute myocardial infarction had a higher risk of death from all causes at one year after acute myocardial infarction than their HIV-negative counterparts (hazard ratio 4.42). There was no statistically significant difference in the risk of recurrent acute myocardial infarction or hospital admission in this group.
These findings point out that HIV-infected individuals could benefit from better-informed cardiac risk stratifications as well as targeted secondary prevention measures.