7. IRIS (Immune Reconstitution Inflammatory Syndrome)

7.1 IRIS induced by antiretroviral therapy in case of adequately treated opportunistic disease
7.2 IRIS unmasking prevalent sub-clinical opportunistic disease
7.3 IRIS in the case of chronoc viral hepatitis B or C
7.4 IRIS manifesting as autoimmune disorder

 

7.1 IRIS induced by antiretroviral therapy in case of adequately treated opportunistic disease

  1. The patient had a diagnosis of an opportunistic disease which has been (or is still) adequately treated, and
  2. Symptoms consistent with an infectious/inflammatory condition appearing within three months of a new antiretroviral therapy (first ART or change of a failing regimen), and
  3. These symptoms can not be explained by a newly aquired infection, nor by the expected clinical course of a previously recognized infectious agent, nor by side effects of therapy.

The date of IRIS is introduced in the DISEASE form on the line of the respective opportunistic disease in the column IRIS. The date of IRIS is greater than the date of diagnosis (NEW-date).

 

7.2 IRIS unmasking prevalent sub-clinical opportunistic disease

  1. Symptoms consistent with an infectious/inflammatory condition that appear within three months of a newly started antiretroviral therapy (first ART or change of a failing regimen), and
  2. Symptoms can be attributed to a new opportunistic disease and, according to the treating physician, can not be explained by a newly aquired infection but by unmasking of a subclinical opportunistic disease and can not be explained by side effects of therapy.

The date of IRIS is equal to the date of diagnosis (NEW-date). Both dates are introduced in the DISEASE form on the line of the respective opportunistic disease.

 

7.3 IRIS in the case of chronic viral hepatitis B or C

  1. A hepatitis flare up occurs within three months of a new antiretroviral therapy (first ART or change of a failing regimen), and
  2. Can not be explained by a newly acquired infection or by the expected clinical course according to chronic hepatitis or by side effects of therapy according to the treating physician.

The date of IRIS is introduced in the DISEASE form on the corresponding field.

 

7.4 IRIS manifesting as autoimmune disorder

An autoimmune disorder occuring within three years of a new immunonologically successful antiretroviral therapy (first ART or change of a failing regimen).

The date of IRIS is introduced in the DISEASE form on one of the lines (autoimmune). The type of the autoimmune disorder is specified.